Dose-dependent beneficial effect of melatonin on obesity; interaction of melatonin and leptin

Melatonin and obesity

  • Yaiza Potes Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, 33006, Oviedo, Spain and Instituto de Investigación Sanitaria del Principado de Asturias (IISPA), 33011 Oviedo, Spain
  • Beatriz de Luxán-Delgado Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, 33006, Oviedo, Spain
  • Adrian Rubio-González Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, 33006, Oviedo, Spain
  • Russel J. Reiter Departmen tof Cell System and Anatomy UT Health, San Antonio, Texas, USA
  • Ana Maria Coto Montes Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, 33006, Oviedo, Spain and Instituto de Investigación Sanitaria del Principado de Asturias (IISPA), 33011 Oviedo, Spain
DOI: https://doi.org/10.32794/mr11250008
Keywords: melatonin, leptin, obesity, ob/ob, UPR, reticulum stress, ATF6α

Abstract

Although numerous studies have noted leptin’s role in obesity, there are still important mechanisms insights that need to be elucidated. Disturbed leptin production is associated with eating disorders, leading to alter food intake and energy expenditure. Proper regulation of protein homeostasis is critical for metabolic diseases such as obesity. Thus, the purpose of the present work was to study the unfolded protein response, which is implicated in the alleviation of endoplasmic reticulum stress-dependent dysregulation of nutritional status. We studied the effect of leptin deficiency on liver, brain and skeletal muscle tissues in obese (ob/ob) mice and the actions of a daily melatonin administration, as a possible treatment. Our findings showed that the leptin-deficient mice presented tissue-specific alterations of the three adaptive unfolded protein responses. ATF6α arm is strongly activated in all of them, indicating a deregulated lipid metabolism by the lack of leptin. Likewise, melatonin also alleviates unfolded protein response in a tissue-specific manner, acting mainly in the restoration of this disturbed ATF6α pathway. These findings support the use of melatonin as a potential therapeutic treatment against leptin-associated disorders.

 

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Published
2019-02-28
How to Cite
[1]
Potes, Y., de Luxán-Delgado, B., Rubio-González, A., Reiter, R.J. and Coto Montes, A. 2019. Dose-dependent beneficial effect of melatonin on obesity; interaction of melatonin and leptin. Melatonin Research. 2, 1 (Feb. 2019), 1-8. DOI:https://doi.org/https://doi.org/10.32794/mr11250008.
Issue
Vol 2 No 1 (2019): Melatonin research
Section
Research Articles
DOI
https://doi.org/10.32794/mr11250008
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